Tag: Organic Chemistry
Heteroleptic carbones are predicted to be stable and often bent
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in ChemistryWhat the study found The calculations suggest that the heteroleptic carbones L1-C-L2 are generally stable enough to be experimentally observed. Most of these complexes are predicted to have bent equilibrium structures, with two exceptions that are linear. Why the authors say this matters The authors conclude that comparing heteroleptic carbones with homoleptic species helps show…
Trifluoromethyl copper complexes were repurposed for saccharide difluoromethylation
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in ChemistryPhoto- and acid-mediated repurposing of Grushin’s reagent enables efficient difluoromethylation of alcohols, saccharides, and bioactive molecules, generating antifungal leads.
Organic-dye CDC method adds fluoronitromethane to tetrahydroisoquinolines
Organocatalytic cross-dehydrogenative coupling of tetrahydroisoquinolines with fluoronitromethane using Rose Bengal and green LED irradiation for sustainable fluorinated compound synthesis.
Desymmetrization method forms N–N atropisomers with multiple stereocenters
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Asymmetric Michael addition constructs N-N atropisomers from indole-derived maleimides with simultaneous generation of multiple stereocenters, achieving 99% yield and exceptional stereoselectivity.
Trans-decalin moiety of pyrroindomycins constructed
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in ChemistryResearchers achieve synthesis of the decalin core of pyrroindomycin natural products, enabling full structural determination and biosynthetic pathway elucidation.
Three-layer strategy produces fused hydantoins and diketopiperazines
A scalable three-layer synthesis strategy rapidly produces thiazolo-hydantoins and diketopiperazines in under 3 hours without chromatography, enabling one-pot processing and late-stage modification.
New sulfanyl indeno triazinones were synthesized and some cyclized further
Novel one-pot synthesis of 3-alkenyl(propargyl)sulfanyl-indeno[1,2-e][1,2,4]triazin-9-ones with selective heterocyclization through halogenation.
Photocatalysis enabled synthesis of trifluoromethyl amidines and imidates
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in ChemistryPhotocatalytic metal-free synthesis of α-trifluoromethyl amidines and imidates using isocyanides and trifluoroacetylsilanes, with mechanistic insights from DFT studies.
Measured pKa values of triorganophosphonium P–H bonds in toluene
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in ChemistryExperimental pKa values of P-H bonds in triorganophosphonium bistriflimides determined in toluene using spectroscopy and DFT, providing guidelines for catalytic phosphine generation.
Electron-withdrawing groups enable thio-Belluš–Claisen rearrangement with difluoroketene
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in ChemistryNew protocol for thio-Belluš-Claisen rearrangement with difluoroketene using desilylative β-elimination. Electronic effects on substrate promotion of reactivity.
