Category: Biochemistry, Genetics and Molecular Biology
Human Pol-PCNA binds DNA in an unexpected extra site
Cryo-EM re-evaluation of human DNA polymerase epsilon-PCNA reveals unexpected multi-site DNA binding behavior contradicting prior mechanistic interpretations of mismatch recognition and proofreading.
Fresh bone samples improved DNA methylation age estimates
Study evaluates methylation-based bone age estimation across anatomical types and postmortem conditions, revealing accuracy limitations under forensic scenarios.
H. pylori genome contains the dciA helicase loader gene
Discovery of dciA gene in Helicobacter pylori challenges established chromosome replication models and reveals limitations in current helicase loader identification methodologies.
SFPQ helps protect repeat DNA from R-loop damage
SFPQ directs histone H3.3 deposition to R-loops in repetitive DNA elements through DAXX recruitment, suppressing replication stress and genome instability while activating innate immune responses.
hsa-miR-96-5p validated as a reference for vitreous humor PMI estimation
Validation of hsa-miR-96-5p as a stable endogenous reference gene for qPCR-based post-mortem interval estimation in vitreous humor forensic analysis.
Review maps gene networks for salt-tolerant crop breeding
Molecular pathways and precision breeding technologies for developing salt-tolerant crop varieties through gene regulatory network analysis and genomic selection approaches.
Microbial metabolite linked to epithelial damage in EAE
Multi-omics study reveals how the microbial metabolite phenyllactic acid drives mitochondrial dysfunction and intestinal barrier damage in experimental autoimmune encephalomyelitis through OXPHOS.
SNP profile completeness varied, but DNA metrics only partly predicted it
Large-scale analysis of DNA quantification metrics and SNP sequencing performance in unidentified human remains shows robust applicability for forensic identification despite moderate predictability.
Pol I transcription is linked to health, disease, and targeted therapy
Integrated analysis of Pol I structural mechanisms, regulatory pathways, disease associations, and emerging therapeutic strategies targeting this essential eukaryotic transcriptional machinery.
Brain organoids may improve human-relevant environmental neurotoxicology
Brain organoids revolutionize environmental neurotoxicology by providing human-relevant models for detecting subtle adverse effects from contaminant exposures, reducing animal testing, and.
