Category: Biochemistry, Genetics and Molecular Biology
High-resolution spatial transcriptomics maps gut microbiome biogeography
Spatial transcriptomics method combining enzymatic polyadenylation and RNA sequencing for high-resolution mapping of host-gut microbiome interactions and microbial biogeography.
Urine metabolomics showed distinct patterns across paediatric TB states
Urine metabolomics via NMR spectroscopy shows promise for early diagnosis of paediatric tuberculosis, achieving 97% accuracy in distinguishing active TB from latent infection.
CTF18–RFC structure shows distinctive PCNA-loading features
Cryo-EM structure of human CTF18–RFC clamp loader bound to PCNA reveals autoinhibited conformation and unique structural features governing leading strand synthesis.
Molecular markers improved garlic characterization and conservation
Explore how molecular markers advance garlic genetic characterization and conservation, from early markers to high-resolution platforms enabling cultivar identification and breeding innovation.
EV delivery of miR-181a-3p protected degenerating retinal ganglion cells
Extracellular vesicles deliver miR-181a-3p to protect degenerating retinal ganglion cells, offering a novel therapeutic approach for glaucoma and optic neuropathies through biocompatible gene.
Bora links Aurora-A activation to PLK1 recognition
Structural analysis revealing how the intrinsically disordered protein Bora bridges Aurora-A kinase and PLK1 substrate recognition through phosphorylation-dependent mechanisms during mitotic entry.
Neolithic paternal lineages linked China and Mainland Southeast Asia
Ancient and modern Y-chromosome analysis reveals how Neolithic millet and rice farmers from China migrated into Southeast Asia, shaping paternal genetic diversity and ethnolinguistic populations.
Bark microbes in Australian forests metabolize climate-active gases
Bark microbiota in Australian forests metabolize climate-active gases through specialized bacterial communities adapted to dynamic redox environments, with implications for atmospheric cycling rates.
5500-year-old Treponema pallidum genome found in Colombia
A 5,500-year-old Treponema pallidum genome from Tequendama I, Colombia, forms a sister lineage to known subspecies, extending treponemal genomic history in the Americas.
