Category: Biochemistry, Genetics and Molecular Biology
BrDMC1 helps pollen meiosis tolerate heat in Brassica rapa
BrDMC1 gene overexpression improves pollen fertility and meiotic stability in Brassica rapa under high-temperature stress by enhancing DNA repair and antioxidant defenses.
Gut microbiota metabolic reprogramming may drive metabolic disease
Dysbiosis-induced microbial metabolic reprogramming drives metabolic disease through alterations in lipid, glucose, amino acid, and uric acid metabolism.
Ancient DNA relatedness methods vary in reliability across conditions
Benchmark evaluation of ancient DNA genetic relatedness estimation methods reveals multiple sources of bias and limitations in current approaches.
AOH1996 remained the most active PCNA inhibitor analog
Synthesis and anticancer evaluation of PCNA inhibitor AOH1996 analogs in MCF-7 and U87 cancer cell cultures with SAR analysis and ADMET prediction
Antibiotic use was linked to long-lasting gut microbiome changes
Population-based study linking 8-year antibiotic prescription data with fecal metagenomes in 14,979 adults to characterize associations between oral antibiotic use and gut microbiome composition.
Mitotic repair pathway drives chromoanasynthesis
Study reveals mitotic microhomology-mediated break-induced replication drives chromoanasynthesis, a complex chromosomal rearrangement mechanism in cancer and congenital disorders.
Ecological network balance index distinguishes healthy and dysbiotic gut states
Ecological network balance index quantifies positive and negative microbial interactions as a marker of dysbiosis, differentiating health from disease states with mechanistic grounding.
C. elegans lifespan is limited by different competing causes of death
Study reveals how multiple age-related pathologies interact hierarchically to determine lifespan in C. elegans, showing bacterial infection and neoplasia mask or unmask each other’s effects on.
Review highlights histone marks in C. elegans embryonic cell cycle
Explore histone modifications during C. elegans embryonic cell division, examining H4K20me1, H3S10ph, and other epigenetic marks that regulate chromatin dynamics and mitotic progression.
Nasal microbiome linked to small-to-modest epigenome variation in adolescents
Nasal microbiome composition shows modest but significant associations with epigenomic variation among adolescents, warranting investigation of environmental and developmental factors.
