Tag: Organic Chemistry
Chiral carbon-bonding donors showed asymmetric induction
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Carbon-bonding donors induce asymmetric induction via noncovalent interaction, demonstrated through oxa-Pictet-Spengler cyclization with oxocarbenium intermediates.
Indole-based synthesis yields α-perfluoroalkylamino derivatives
Novel sequential perfluoroalkylation and defluoroamination of indoles via sulfinate-derived radicals and HMDS-mediated C-F cleavage, yielding α-trifluoromethylated amines in up to 80% yield.
Thiolate-mediated cyclization yields 2-quinolones from aminocinnamic acids
Thiolate-mediated cyclization protocol for synthesis of 2-quinolones and 2-aza-quinolones from aminocinnamic acid derivatives with broad substrate scope and gram-scale scalability.
2-Lithiomethylindoles enable diverse 2-functionalized indoles
Optimized α-lithiation protocol for 1,2-dimethylindoles enables efficient C2-functionalization via diverse electrophile trapping in deep eutectic solvents under air-tolerant conditions.
Low-temperature lithium-metal batteries improved by hierarchical solvation
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in ChemistryHierarchical solvating electrolyte enables high-performance lithium-metal batteries at extreme low temperatures through molecular engineering of solvation sheaths and solid electrolyte interphase.
Pyridinium catalysis enables stereoselective 2-deoxy-2-fluoroglycoside assembly
Pyridinium-catalyzed stereoselective synthesis of 2-deoxy-2-fluoroglycosides via syn-addition to 2-fluoroglycals with mechanistic insights from NMR and DFT studies.
Gallic acid ester activity changed with chain length and hydroxyl groups
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in ChemistrySystematic evaluation of 14 gallic acid ester derivatives reveals inverse relationship between alkyl chain length and antioxidant activity, while hydroxyl substitution maintains efficacy.
Photoredox method enables deoxytrifluoromethoxylation of phenols
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in ChemistryPhotoredox-catalyzed deoxytrifluoromethoxylation installs OCF3 groups on phenols via in situ difluorophosgene generation and aryl carbonofluoridate activation.
Phenanthrenone-derived ketone is more electrophilic than acenaphthenone-derived ketone
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in ChemistryKinetic and computational quantification of electrophilicity for phenanthrenone‑ and acenaphthenone‑derived α,β‑unsaturated ketones: Mayr E parameters, transition‑state analysis, and.
Metal-free trifluoromethylalkynylation of unsaturated peptides
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in ChemistryMetal-free concurrent trifluoromethyl and alkynyl installation on unsaturated peptides under mild conditions, enabling rapid access to multifunctional peptide scaffolds for medicinal chemistry.
