Tag: Molecular Biology
hsa-miR-96-5p validated as a reference for vitreous humor PMI estimation
Validation of hsa-miR-96-5p as a stable endogenous reference gene for qPCR-based post-mortem interval estimation in vitreous humor forensic analysis.
Microbial metabolite linked to epithelial damage in EAE
Multi-omics study reveals how the microbial metabolite phenyllactic acid drives mitochondrial dysfunction and intestinal barrier damage in experimental autoimmune encephalomyelitis through OXPHOS.
Pol I transcription is linked to health, disease, and targeted therapy
Integrated analysis of Pol I structural mechanisms, regulatory pathways, disease associations, and emerging therapeutic strategies targeting this essential eukaryotic transcriptional machinery.
High-resolution spatial transcriptomics maps gut microbiome biogeography
Spatial transcriptomics method combining enzymatic polyadenylation and RNA sequencing for high-resolution mapping of host-gut microbiome interactions and microbial biogeography.
Gut microbiome is linked to colorectal cancer development and management
—
Review of gut microbiome mechanisms in colorectal cancer carcinogenesis, examining pathogenic bacteria, protective functions, biomarker development, and therapeutic strategies.
CTF18–RFC structure shows distinctive PCNA-loading features
Cryo-EM structure of human CTF18–RFC clamp loader bound to PCNA reveals autoinhibited conformation and unique structural features governing leading strand synthesis.
Molecular markers improved garlic characterization and conservation
Explore how molecular markers advance garlic genetic characterization and conservation, from early markers to high-resolution platforms enabling cultivar identification and breeding innovation.
EV delivery of miR-181a-3p protected degenerating retinal ganglion cells
Extracellular vesicles deliver miR-181a-3p to protect degenerating retinal ganglion cells, offering a novel therapeutic approach for glaucoma and optic neuropathies through biocompatible gene.
Bora links Aurora-A activation to PLK1 recognition
Structural analysis revealing how the intrinsically disordered protein Bora bridges Aurora-A kinase and PLK1 substrate recognition through phosphorylation-dependent mechanisms during mitotic entry.
Baby-to-baby strain transmission shapes infant gut microbiome
—
in MicrobiologyStudy reveals how baby-to-baby microbiome transmission in nurseries substantially shapes infant gut health during the first year, complementing maternal microbial inheritance.
