Tag: Molecular Biology
PAF15-PCNA exhaustion limits strand-specific DNA replication control
Study reveals PAF15-PCNA interaction as a strand-specific constraint that couples lagging-strand synthesis capacity to global DNA replication control through dosage-sensitive mechanism.
Mycobacterial gyrase inhibition depends on DNA topology
Study reveals that antibacterial drugs inhibit different gyrase-mediated catalytic activities at varying concentrations, with DNA topology modulating drug potency beyond DNA cleavage mechanisms.
BrDMC1 helps pollen meiosis tolerate heat in Brassica rapa
BrDMC1 gene overexpression improves pollen fertility and meiotic stability in Brassica rapa under high-temperature stress by enhancing DNA repair and antioxidant defenses.
Genomic factors linked to tandem repeat mutability
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in GeneticsStudy reveals genomic factors shaping tandem repeat mutagenesis using long-read sequencing across a four-generation pedigree, identifying associations with TR length, motif composition, and.
Review highlights histone marks in C. elegans embryonic cell cycle
Explore histone modifications during C. elegans embryonic cell division, examining H4K20me1, H3S10ph, and other epigenetic marks that regulate chromatin dynamics and mitotic progression.
Nasal microbiome linked to small-to-modest epigenome variation in adolescents
Nasal microbiome composition shows modest but significant associations with epigenomic variation among adolescents, warranting investigation of environmental and developmental factors.
Human Pol-PCNA binds DNA in an unexpected extra site
Cryo-EM re-evaluation of human DNA polymerase epsilon-PCNA reveals unexpected multi-site DNA binding behavior contradicting prior mechanistic interpretations of mismatch recognition and proofreading.
H. pylori genome contains the dciA helicase loader gene
Discovery of dciA gene in Helicobacter pylori challenges established chromosome replication models and reveals limitations in current helicase loader identification methodologies.
Purple barley showed higher quercetin-related gene expression
Transcriptome analysis reveals how purple barley accumulates quercetin through coordinated expression of biosynthesis genes during grain maturation, with implications for crop improvement and.
SFPQ helps protect repeat DNA from R-loop damage
SFPQ directs histone H3.3 deposition to R-loops in repetitive DNA elements through DAXX recruitment, suppressing replication stress and genome instability while activating innate immune responses.
