Tag: Fluorine in Organic Chemistry
Target-only PFAS data can still differentiate overlapping sources
Tiered PFAS fingerprinting framework for source differentiation using targeted analytics, diagnostic ratios, isomer patterns, and geospatial analysis in complex industrial groundwater settings.
Indole-based synthesis yields α-perfluoroalkylamino derivatives
Novel sequential perfluoroalkylation and defluoroamination of indoles via sulfinate-derived radicals and HMDS-mediated C-F cleavage, yielding α-trifluoromethylated amines in up to 80% yield.
Visible-light photocatalyst achieves near-complete PFAS defluorination
Visible-light photocatalytic defluorination of PFAS using stabilized porphyrin radicals achieving near-complete conversion without additives.
Pentafluoroethylation of styrenes expanded by a sulfoximine reagent
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in ChemistrySynthesis and photocatalytic application of pentafluoroethyl sulfoximine for difunctionalization of styrenes via concurrent C-C and C-heteroatom bond formation under mild conditions.
Pyridinium catalysis enables stereoselective 2-deoxy-2-fluoroglycoside assembly
Pyridinium-catalyzed stereoselective synthesis of 2-deoxy-2-fluoroglycosides via syn-addition to 2-fluoroglycals with mechanistic insights from NMR and DFT studies.
Photoredox method enables deoxytrifluoromethoxylation of phenols
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in ChemistryPhotoredox-catalyzed deoxytrifluoromethoxylation installs OCF3 groups on phenols via in situ difluorophosgene generation and aryl carbonofluoridate activation.
Metal-free trifluoromethylalkynylation of unsaturated peptides
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in ChemistryMetal-free concurrent trifluoromethyl and alkynyl installation on unsaturated peptides under mild conditions, enabling rapid access to multifunctional peptide scaffolds for medicinal chemistry.
