Tag: Fluorine in Organic Chemistry
Trifluoromethyl copper complexes were repurposed for saccharide difluoromethylation
—
in ChemistryPhoto- and acid-mediated repurposing of Grushin’s reagent enables efficient difluoromethylation of alcohols, saccharides, and bioactive molecules, generating antifungal leads.
Organic-dye CDC method adds fluoronitromethane to tetrahydroisoquinolines
Organocatalytic cross-dehydrogenative coupling of tetrahydroisoquinolines with fluoronitromethane using Rose Bengal and green LED irradiation for sustainable fluorinated compound synthesis.
F6H8 altered human liver cell metabolism and produced a PFAS-like metabolite
—
in BiochemistryF6H8, an ophthalmic treatment for dry eye, produces PFAS-like metabolites and triggers broad metabolic disruption in human hepatocytes, raising long-term safety concerns.
Photocatalysis enabled synthesis of trifluoromethyl amidines and imidates
—
in ChemistryPhotocatalytic metal-free synthesis of α-trifluoromethyl amidines and imidates using isocyanides and trifluoroacetylsilanes, with mechanistic insights from DFT studies.
PFOS detected rapidly with a dual-recognition chemiresistive sensor
Chemiresistive sensor with molecularly imprinted polymer and fluorine-fluorine interactions achieves 1.3 ng·L⁻¹ detection of PFOS in environmental samples with validated accuracy.
Home-produced eggs had the highest PFAS levels in Croatia
Study measuring per- and polyfluoroalkyl substances in Croatian eggs across production systems, identifying home-produced eggs as significantly more contaminated and young children as most vulnerable.
Electron-withdrawing groups enable thio-Belluš–Claisen rearrangement with difluoroketene
—
in ChemistryNew protocol for thio-Belluš-Claisen rearrangement with difluoroketene using desilylative β-elimination. Electronic effects on substrate promotion of reactivity.
Modular synthesis of CF3/CHF2 dihydroquinoline sulfonyl fluorides
Modular synthesis of CF3/CHF2-substituted dihydroquinoline sulfonyl fluorides via [4+2] cycloaddition and sulfur(VI) fluoride exchange without transition metal catalysis.
THF increased yields of polyfluorinated tetraketones
—
in ChemistrySynthesis of polyfluorinated diketoesters and tetraketones from perfluorinated dicarboxylic acid esters and alkyl ketones, with mechanistic investigation via MP2 calculations.
Stereochemical assignment of trifluoroacetamides using NMR signals
—
in ChemistryStereochemical assignment of N,N-dialkyl trifluoroacetamides using integrated analysis of through-space 1H···19F spin-spin couplings and aromatic solvent-induced shifts in 1H-NMR spectroscopy.
