Tag: Analytical chemistry methods development
RP-HPLC accurately quantified metoprolol and enalapril maleate
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in ChemistryRP-HPLC method for simultaneous quantification of metoprolol and enalapril maleate using environmentally sustainable approach with recovery rates of 98–102% and validation per ICH criteria.
Trace ethylene boosts nitrogen GC-MS sensitivity
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Adding trace ethylene to nitrogen carrier gas in GC-MS increases sensitivity 20-fold while maintaining 70 eV electron-ionization spectral patterns compatible with existing reference libraries.
RFS mode improved chromatography efficiency and lowered pressure
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Novel radial flow stream splitting HPLC columns reduce analysis time by 40 percent while maintaining quantitative accuracy for pharmaceutical drug testing.
Miniaturized extraction selectively enriched toxicologically relevant MOAH
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in ChemistryMiniaturized extraction selectively enriches trace polycyclic aromatics in mineral oils, improving detection of genotoxic compounds masked by abundant alkylated aromatics in complex mixtures.
Headspace gas chromatography may support food authenticity analysis
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Static headspace sampling with cryogenic modulation GC×GC-TOFMS enables comprehensive volatile and chiral analysis of citrus essential oils, eliminating solvents while improving detectability for.
Light-controlled cellulose sorbent enabled amphetamine extraction
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in ChemistryLight-driven cellulose-azobenzene sorbent for amphetamine extraction with UV-triggered 90% desorption efficiency and validated HPLC-UV method.
Validated HPLC method measures polysorbate 80 in mAbs
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in ChemistryInterlaboratory validated HPLC-ELSD method for accurate polysorbate 80 quantification in monoclonal antibody formulations with robust performance across diverse laboratory settings.
