What the study found
Prenatal exposure to acid-suppressive medication was not associated with children's risk of ADHD, severe neuropsychiatric disorder, obsessive-compulsive disorder, intellectual disability, or ASD in sibling-control analyses.
Why the authors say this matters
The findings indicate that the small associations seen in other models may reflect confounding by shared familial factors, according to the authors.
What the researchers tested
The researchers examined prenatal exposure to acid-suppressive medications and its association with neuropsychiatric disorders in children. They compared results from sibling-control analyses with overlap-weighted models.
What worked and what didn't
In sibling-control analyses, no association was found between prenatal acid-suppressive medication exposure and the listed child outcomes. Small associations were observed in overlap-weighted models, but the abstract states these may reflect confounding by shared familial factors.
What to keep in mind
The abstract does not provide additional details about the study design, sample, or limitations beyond the comparison of sibling-control analyses and overlap-weighted models.
Key points
- Prenatal acid-suppressive medication exposure was not associated with ADHD in sibling-control analyses.
- No association was reported for severe neuropsychiatric disorder, obsessive-compulsive disorder, intellectual disability, or ASD in sibling-control analyses.
- Small associations appeared in overlap-weighted models, but the authors suggest these may be due to shared familial factors.
Disclosure
- Research title:
- Prenatal acid-suppressive drugs were not linked to child neuropsychiatric risk in sibling analyses
- Authors:
- Seohyun Hong, Sooji Lee, Hyunjee Kim, Hyesu Jo, Kyeongmin Lee, Yeona Jo, Tae Hyeon Kim, Jaeyu Park, Jinseok Lee, Ho Geol Woo, Hayeon Lee, Dong Keon Yon
- Institutions:
- Kyung Hee University, Kyung Hee University Medical Center
- Publication date:
- 2026-01-07
- OpenAlex record:
- View
- Image credit:
- Photo by Polina Tankilevitch on Pexels · Pexels License
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