Focal Interest
Focal Interest

Renal Transplantation Outcomes and Treatments

External reference: https://openalex.org/T10373

  1. Donor TNFα linked to worse kidney graft outcomes
    High circulating tumor necrosis factor α in deceased organ donors associates with inferior kidney graft function and survival after transplantation through TNFR1-mediated injury mechanisms.
  2. Donor acceptance patterns in pancreas transplant changed over time
    Population cohort study reveals declining DCD pancreas utilization despite good outcomes, while Hepatitis C and IVDU donors gain acceptance in transplantation practice.
  3. Donor age affects younger liver transplant recipients more
    Donor age disproportionately impacts younger liver transplant recipients while older recipients tolerate older grafts well. Study provides age-based thresholds for optimized donor-recipient matching.
  4. SIPAT evaluation highlights alcohol use and education
    Domain-level SIPAT assessment reveals alcohol use and lower education as primary psychosocial vulnerabilities across transplant candidates, supporting targeted pre-transplant evaluation.
  5. Psychological interventions may improve transplant-related well-being
    Systematic review commentary on psychological interventions in organ transplantation, examining placebo and nocebo effects as overlooked explanatory mechanisms for clinical outcomes.
  6. MuST AKT was feasible and acceptable in a pilot trial
    MuST AKT pilot trial tests structured intervention to increase living donor kidney transplants through multidisciplinary support and social network engagement.
  7. Wait time policy increased transplant rates for Black candidates
    Quasi-experimental evaluation of wait time modification policy effects on Black kidney transplant candidates, addressing race-based kidney function estimation bias in allocation algorithms.
  8. dd-cfDNA tracks kidney rejection activity across the continuum
    Donor-derived cell-free DNA quantifies kidney allograft rejection non-invasively across histopathological spectra, with combined scoring optimizing detection of microvascular and antibody-mediated.
  9. Review of psychosocial challenges in transplantation
    Review of psychosocial challenges in transplantation with emphasis on lung-specific studies, guidelines, and research gaps for clinical practice.
  10. Mild AKI in elderly kidney donors did not worsen graft outcomes
    Kidney transplantation from elderly donors with mild acute kidney injury yields comparable graft survival and function to non-AKI donors, supporting expanded utilization in recipient selection.
  11. XGBoost performed best for predicting late eGFR after kidney transplant
    Machine learning models combined with Monte Carlo simulation predict late kidney transplant function using tacrolimus pharmacokinetics and clinical parameters.