Focal Interest
Focal Interest

DNA Repair Mechanisms

External reference: https://openalex.org/T10123

  1. Bora links Aurora-A activation to PLK1 recognition
    Structural analysis revealing how the intrinsically disordered protein Bora bridges Aurora-A kinase and PLK1 substrate recognition through phosphorylation-dependent mechanisms during mitotic entry.
  2. Chromosome-specific differences in the recombination landscape of spontaneous meiotic nondisjunction
    Whole-genome sequencing of Drosophila reveals chromosome-specific recombination patterns in meiotic nondisjunction, with metacentric chromosome 2 showing reduced recombination.
  3. Cryo-EM reveals multiple cytochrome P450 reductase conformations
    3.3 Å cryo-EM of full-length rat cytochrome P450 reductase reveals a relaxed compact state, additional compact variants, and ~20% of particles with displaced or missing FMN domain.