Category: Cancer research
Tucidinostat plus R-CHOP improved event-free survival in DEL
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What the study found The study found that adding tucidinostat, an oral histone deacetylase inhibitor, to R-CHOP improved outcomes for people with newly diagnosed MYC/BCL2 double-expressor lymphoma, a type of diffuse large B-cell lymphoma marked by coexpression of the MYC and BCL2 proteins. The combination was associated with better event-free survival and a higher complete…
PFOA-linked bladder cancer signals identified in transcriptomic analysis
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Study reveals molecular mechanisms linking PFOA exposure to bladder cancer through integrative toxicogenomics and gene expression analysis, identifying key transcriptional signatures for cancer.
Prunus africana bark extract showed selective cytotoxicity in prostate cancer cells
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In vitro evaluation of Prunus africana extract cytotoxicity on hormonally insensitive prostate cancer C4-2 cells via apoptosis-mediated mechanisms.
Gut microbiome is linked to colorectal cancer development and management
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Review of gut microbiome mechanisms in colorectal cancer carcinogenesis, examining pathogenic bacteria, protective functions, biomarker development, and therapeutic strategies.
Three biomarkers were linked to angiogenesis and ISR in chondrosarcoma
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Multi-omics analysis identifies HSPA8, LMNA, and SERPINH1 as angiogenesis and integrated stress response biomarkers in chondrosarcoma with therapeutic potential.
