Category: Biochemistry
Polyphenols show both beneficial and harmful dose-dependent effects
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in BiochemistryReview examines the paradoxical bioactivity of polyphenols: beneficial antioxidant effects at dietary levels versus pro-oxidant toxicity, carcinogenicity, and organ damage at high supplemental doses.
F6H8 altered human liver cell metabolism and produced a PFAS-like metabolite
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in BiochemistryF6H8, an ophthalmic treatment for dry eye, produces PFAS-like metabolites and triggers broad metabolic disruption in human hepatocytes, raising long-term safety concerns.
Plant polyphenols are linked to antioxidant and anti-inflammatory mechanisms
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in BiochemistryEvidence synthesis on polyphenol antioxidant mechanisms, redox signaling, and bioavailability constraints across disease contexts, emphasizing dose realism and microbiota variability.
Aromatic Indian teas showed stronger bioactivity in several tests
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in BiochemistryHPTLC analysis and molecular docking reveal that spice-enriched Indian black teas contain elevated phenolic compounds with strong antioxidant and antidiabetic activity in cellular assays.
Saffron floral residues showed antimicrobial and antioxidant activity
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in BiochemistryPhytochemical and antimicrobial evaluation of Crocus sativus tepal extracts reveals bioactive metabolites with therapeutic potential against resistant bacterial pathogens.
Cryo-EM reveals multiple cytochrome P450 reductase conformations
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in Biochemistry3.3 Å cryo-EM of full-length rat cytochrome P450 reductase reveals a relaxed compact state, additional compact variants, and ~20% of particles with displaced or missing FMN domain.
