What the study found
The study found that serum cyclophilin A, a protein involved in inflammation and vascular dysfunction, was higher in women with preeclampsia than in healthy controls in both the first and third trimesters. The authors report that this pattern suggests a trimester-specific association with preeclampsia.
Why the authors say this matters
The authors suggest that cyclophilin A may be relevant to the pathogenesis of preeclampsia, a major cause of maternal-fetal morbidity. They conclude that the trimester-specific pattern warrants further investigation.
What the researchers tested
The researchers conducted a prospective case-control study of 120 pregnant women without prior medical conditions. They measured serum cyclophilin A in the first trimester for all participants and again in the third trimester for women who developed preeclampsia, then compared levels between preeclampsia and control groups and between early-onset and late-onset preeclampsia subgroups.
What worked and what didn't
Maternal age, gravidity, and parity did not differ significantly between the preeclampsia and control groups. Cyclophilin A concentrations were markedly elevated in the preeclampsia group compared with healthy controls in both trimesters, and early-onset preeclampsia was associated with significantly higher cyclophilin A levels than late-onset preeclampsia in both trimesters.
What to keep in mind
The abstract does not describe limitations in detail. The findings are based on a single prospective case-control study in women without prior medical conditions, so the scope is limited to that population.
Key points
- Cyclophilin A was higher in women with preeclampsia than in healthy controls in both the first and third trimesters.
- Women who later developed preeclampsia already had higher first-trimester cyclophilin A levels.
- Early-onset preeclampsia was associated with higher cyclophilin A levels than late-onset preeclampsia.
- The study included 120 pregnant women without prior medical conditions.
- The authors say the trimester-specific pattern warrants further investigation.
Disclosure
- Research title:
- Cyclophilin A was higher in preeclampsia across pregnancy
- Authors:
- Neşet Gümüşburun, Selim Gulucu, Sebahattin ÇELİK, Sercan Serin
- Institutions:
- Balıkesir University, Istanbul Aydın University, Samsun University, Tokat Gaziosmanpaşa Üniversitesi
- Publication date:
- 2026-03-10
- OpenAlex record:
- View
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