Tag: Inflammasome and immune disorders
CASP5C amplifies Wnt signaling in human intestinal epithelium
What the study found CASP5C, one of three CASP5 isoforms, is the form that uniquely promotes Wnt signaling in the human intestinal epithelium. The authors report that it does so by cleaving APC, a scaffold protein in the β-catenin destruction complex, which helps sustain intestinal epithelial renewal. Why the authors say this matters The authors…
Tmem178 suppresses NLRP3 activation in osteoclasts
What the study found Tmem178, a protein that limits calcium (Ca2+) entry by restraining store-operated calcium entry, suppresses NLRP3 inflammasome activation in osteoclasts, the bone-resorbing cells. The abstract states that this restraint also limits the bone-resorbing activity of osteoclasts. Why the authors say this matters The authors conclude that Tmem178 potently restricts Ca2+ influx in…