Tag: Immunology
TREM2-endothelial signaling impairs ischemic vascular repair in diabetes
What the study found The study found that diabetes-associated signaling involving TREM2, a receptor on mononuclear phagocytes, and endothelial cells is linked to impaired repair of ischemic blood vessels. The authors describe TREM2-endothelial cell interaction as a driver of diabetic vasculopathy. Why the authors say this matters The authors conclude that this interaction may be…
Some pyrazoloquinazoline compounds showed TLR7/8 antagonism
What the study found A pyrazolo[1,5-c]quinazoline scaffold was explored for activity at toll-like receptors 7 and 8 (TLR7/8), proteins involved in immune signaling. One compound showed moderate agonist activity for both TLR7 and TLR8, and three related compounds were identified as dual TLR7/8 antagonists. Why the authors say this matters The authors state that these…