Tag: Genetics & Genomics
Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks
Tel1-mediated negative feedback propagates locally to reshape genome-wide meiotic DSB patterns in yeast, demonstrating how localized regulation drives emergent patterning.
A Spatio-Temporal Analysis Framework for Characterizing Radiation-Induced Genomic Instability
Integrated analytical framework reveals 7.13-fold enrichment of doublet base substitutions at inversion breakpoints in chronic low-dose radiation exposure of human cells.
Explaining the unexplained admixture mapping signals via rare variants: the HCHS/SOL
Study finds common variants in extended genomic regions, not rare variants, explain most unexplained admixture mapping signals in Hispanic/Latino populations.
Chromosome-specific differences in the recombination landscape of spontaneous meiotic nondisjunction
Whole-genome sequencing of Drosophila reveals chromosome-specific recombination patterns in meiotic nondisjunction, with metacentric chromosome 2 showing reduced recombination.
