Tag: Genetic Associations and Epidemiology

What the study found The study found that human pancreatic alpha and beta cells have many cell-specific DNA methylation differences, and that some of these differences are linked to changes in gene expression. It also identified methylation changes associated with pre-type 2 diabetes and type 2 diabetes in both cell types. Why the authors say…

What the study found The study found that pancreatic beta cells show progressive age-related DNA methylation changes, including demethylation at regions linked to beta cell identity and function genes. In type 2 diabetes (T2D), beta cells showed further demethylation compared with healthy controls, while alpha cells did not show the same pattern. Why the authors…