Tag: Epigenetics and DNA Methylation
Cell-specific methylation changes in alpha and beta cells in type 2 diabetes
—
in MedicineWhat the study found The study found that human pancreatic alpha and beta cells have many cell-specific DNA methylation differences, and that some of these differences are linked to changes in gene expression. It also identified methylation changes associated with pre-type 2 diabetes and type 2 diabetes in both cell types. Why the authors say…
Beta cell DNA methylation changes with age and in T2D
—
in MedicineWhat the study found The study found that pancreatic beta cells show progressive age-related DNA methylation changes, including demethylation at regions linked to beta cell identity and function genes. In type 2 diabetes (T2D), beta cells showed further demethylation compared with healthy controls, while alpha cells did not show the same pattern. Why the authors…
Fresh bone samples improved DNA methylation age estimates
Study evaluates methylation-based bone age estimation across anatomical types and postmortem conditions, revealing accuracy limitations under forensic scenarios.
