Tag: DNA
PAF15-PCNA exhaustion limits strand-specific DNA replication control
Study reveals PAF15-PCNA interaction as a strand-specific constraint that couples lagging-strand synthesis capacity to global DNA replication control through dosage-sensitive mechanism.
Mycobacterial gyrase inhibition depends on DNA topology
Study reveals that antibacterial drugs inhibit different gyrase-mediated catalytic activities at varying concentrations, with DNA topology modulating drug potency beyond DNA cleavage mechanisms.
Review highlights histone marks in C. elegans embryonic cell cycle
Explore histone modifications during C. elegans embryonic cell division, examining H4K20me1, H3S10ph, and other epigenetic marks that regulate chromatin dynamics and mitotic progression.
SFPQ helps protect repeat DNA from R-loop damage
SFPQ directs histone H3.3 deposition to R-loops in repetitive DNA elements through DAXX recruitment, suppressing replication stress and genome instability while activating innate immune responses.
DBSCAN estimates DNA damage yields from ion beam quality
DBSCAN algorithm predicts DNA damage yields and assesses beam quality for proton and carbon ion irradiation with a novel Quality of Beam metric for radiotherapy.
Low-energy electrons selectively cleaved DNA bonds in films
Study reveals energy-dependent selective bond cleavage in DNA films exposed to low-energy electrons using XPS analysis, showing preferential damage to N-glycosidic and sugar-phosphate bonds.
SNP profile completeness varied, but DNA metrics only partly predicted it
Large-scale analysis of DNA quantification metrics and SNP sequencing performance in unidentified human remains shows robust applicability for forensic identification despite moderate predictability.
CTF18–RFC structure shows distinctive PCNA-loading features
Cryo-EM structure of human CTF18–RFC clamp loader bound to PCNA reveals autoinhibited conformation and unique structural features governing leading strand synthesis.
