Tag: DNA Repair Mechanisms
Talazoparib resistance in triple-negative breast cancer linked to BRN2 and SHLD2
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in OncologyStudy identifies BRN2-mediated and SHLD2-related resistance to talazoparib in BRCA-mutant breast cancer, proposing combination therapy approaches to improve neoadjuvant treatment outcomes.
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
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in NeuroscienceStudy reveals how elevated DNA damage and impaired repair mechanisms drive selective vulnerability of cortical neurons in MS and neuroinflammation.
PAF15-PCNA exhaustion limits strand-specific DNA replication control
Study reveals PAF15-PCNA interaction as a strand-specific constraint that couples lagging-strand synthesis capacity to global DNA replication control through dosage-sensitive mechanism.
Mitotic repair pathway drives chromoanasynthesis
Study reveals mitotic microhomology-mediated break-induced replication drives chromoanasynthesis, a complex chromosomal rearrangement mechanism in cancer and congenital disorders.
Human Pol-PCNA binds DNA in an unexpected extra site
Cryo-EM re-evaluation of human DNA polymerase epsilon-PCNA reveals unexpected multi-site DNA binding behavior contradicting prior mechanistic interpretations of mismatch recognition and proofreading.
SFPQ helps protect repeat DNA from R-loop damage
SFPQ directs histone H3.3 deposition to R-loops in repetitive DNA elements through DAXX recruitment, suppressing replication stress and genome instability while activating innate immune responses.
