Tag: Clinical trial
Mutated clones were usually present before treatment in severe aplastic anemia
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in MedicineWhat the study found The study found that mutated clones were usually present before treatment in patients with severe aplastic anemia, a bone marrow failure disorder. The abstract also states that the researchers characterized clonal dynamics during recovery and progression to myeloid cancer or paroxysmal nocturnal hemoglobinuria (PNH, a condition in which blood cells are…
Online alcohol program reduced drinking in older adults
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in GerontologyWhat the study found An online alcohol intervention for older adults, called Rethink My Drink, reduced monthly alcohol use more than an online information booklet after 12 months. The study did not find a significant difference between groups in global cognition, a measure of overall cognitive performance. Why the authors say this matters The authors…
3D interlocking miniplates improved bone density in mandibular fractures
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in SurgerySplit-mouth trial shows 3D interlocking miniplates produce faster bone healing and better nerve recovery than conventional plates for mandibular fractures near the mental foramen.
Olutasidenib showed disease control in conventional chondrosarcoma
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in OncologyPhase 1b/2 trial of olutasidenib in IDH1-mutated chondrosarcoma shows disease control without dose-limiting toxicities; 52% stable disease rate in recurrent/metastatic disease.
Zuranolone was approved for postpartum depression, not major depressive disorder
Analysis of zuranolone approval reveals how fast-track designations and reduced evidentiary thresholds in drug regulation may inadequately balance innovation with public health protection.
Meloxicam approval in cats is questioned over kidney risk and missing trial data
Examine injectable meloxicam approval for cats, regulatory data discrepancies, acute kidney injury risks, and pharmaceutical sponsorship conflicts in veterinary medicine.
Adjusted light color temperature lowered stress and anxiety
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in ObstetricsRandomized controlled trial examining medium-warm white light effects on stress, anxiety, and psychological well-being in high-risk pregnant women undergoing non-stress testing procedures.
Critically ill COVID-19 trial participants often lacked understanding
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in MedicineQualitative study examining COVID-19 ICU patients’ experiences in REMAP-CAP Japan trial, revealing significant barriers to informed consent comprehension in critical care settings.
PET/CT lesion profiles matched tuberculosis treatment outcomes in marmosets
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in MedicinePET/CT-derived multivariate lesion profiles in M. tuberculosis–infected marmosets predict clinical regimen performance, distinguish cavitary granuloma responses, and outperform bacterial burden.
FMT with immunotherapy showed activity in NSCLC and melanoma
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in OncologyPhase 2 trial: donor FMT plus first-line ICI in NSCLC and melanoma showed high ORRs and implicates loss of specific bacterial taxa in association with response.
