Tag: Cellular and Molecular Neuroscience
Basal ganglia PVS linked to longitudinal cognitive decline
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in NeuroscienceWhat the study found Higher MRI-visible perivascular space (PVS) burden in the basal ganglia, a deep brain region, was associated with worse cognitive performance over time. The strongest independent associations remained for executive function and visuospatial skills. Why the authors say this matters The authors conclude that basal ganglia PVS may be an emerging marker…
Brief electrical stimulation induced ketamine-like plasticity in human neurons
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in NeuroscienceBrief electrical stimulation produces ketamine-like structural plasticity in human dopamine neurons via calcium-dependent BDNF and mTOR signaling, reversing cortisol-induced damage.
Effort boosts dopamine release through acetylcholine
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in NeuroscienceEffort amplifies dopamine reward responses through acetylcholine modulation of dopamine axons in the nucleus accumbens, explaining how organisms maintain reward-seeking under resource constraints.
Neuronal autophagy impairment promotes alpha-synuclein transfer to microglia
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in NeuroscienceNeurons with impaired α-synuclein clearance transfer aggregates to microglia via tunneling nanotubes. Study reveals dysfunctional neuronal autophagy drives intercellular aggregate transfer and.
iPSC-derived neurons showed three distinct functional network stages
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in NeuroscienceStudy characterises functional network development in iPSC-derived neurons over 55 days, identifying three distinct developmental stages with unique activity patterns and communication topologies.
Brain organoids may improve human-relevant environmental neurotoxicology
Brain organoids revolutionize environmental neurotoxicology by providing human-relevant models for detecting subtle adverse effects from contaminant exposures, reducing animal testing, and.
Glial cells tolerated most spinal implant particles
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in Cell biologyAssessment of glial cell responses to spinal implant particles reveals limited inflammatory activation but identifies concerns regarding silicon nitride at elevated concentrations.
