Focal Interest
Focal Interest

Reagent

  1. Trifluoromethyl copper complexes were repurposed for saccharide difluoromethylation
    Photo- and acid-mediated repurposing of Grushin's reagent enables efficient difluoromethylation of alcohols, saccharides, and bioactive molecules, generating antifungal leads.
  2. Measured pKa values of triorganophosphonium P–H bonds in toluene
    Experimental pKa values of P-H bonds in triorganophosphonium bistriflimides determined in toluene using spectroscopy and DFT, providing guidelines for catalytic phosphine generation.
  3. Method distinguishes chiral α-hydroxy acids in complex samples
    MALDI-TIMS-MS platform with chiral derivatization for enantiomeric discrimination of α-hydroxy acids in tumor tissues and food samples with sensitivity to 5.8% enantiomeric ratios.
  4. 2-Lithiomethylindoles enable diverse 2-functionalized indoles
    Optimized α-lithiation protocol for 1,2-dimethylindoles enables efficient C2-functionalization via diverse electrophile trapping in deep eutectic solvents under air-tolerant conditions.
  5. Pentafluoroethylation of styrenes expanded by a sulfoximine reagent
    Synthesis and photocatalytic application of pentafluoroethyl sulfoximine for difunctionalization of styrenes via concurrent C-C and C-heteroatom bond formation under mild conditions.
  6. Metal-free trifluoromethylalkynylation of unsaturated peptides
    Metal-free concurrent trifluoromethyl and alkynyl installation on unsaturated peptides under mild conditions, enabling rapid access to multifunctional peptide scaffolds for medicinal chemistry.