Focal Interest
Focal Interest

Polymerase

  1. DNA replication errors linked to small inverted triplications
    Analysis of cancer genomes reveals FEN1 drives formation of small inverted triplications through replication errors at nucleosome boundaries, with implications for structural variant mechanisms.
  2. Human Pol-PCNA binds DNA in an unexpected extra site
    Cryo-EM re-evaluation of human DNA polymerase epsilon-PCNA reveals unexpected multi-site DNA binding behavior contradicting prior mechanistic interpretations of mismatch recognition and proofreading.
  3. Pol I transcription is linked to health, disease, and targeted therapy
    Integrated analysis of Pol I structural mechanisms, regulatory pathways, disease associations, and emerging therapeutic strategies targeting this essential eukaryotic transcriptional machinery.
  4. CTF18–RFC structure shows distinctive PCNA-loading features
    Cryo-EM structure of human CTF18–RFC clamp loader bound to PCNA reveals autoinhibited conformation and unique structural features governing leading strand synthesis.