Concept: PARP inhibition in cancer therapy

Resistance to neoadjuvant talazoparib in triple-negative breast cancer by BRN2-induced ATR/STAT3 pathways or SHLD2 subclone expansion
Resistance mechanisms to PARP inhibitor therapy in BRCA-mutant breast cancer
April 17, 2026
Image Credit: Photo by National Cancer Institute on Unsplash (Source • License)
Structure of the human CTF18−RFC clamp loader bound to PCNA
Molecular structure reveals how a key protein complex loads DNA replication machinery
March 14, 2026
Image Credit: Photo by This_is_Engineering on Pixabay (Source • License)