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DNA replication errors linked to small inverted triplications
Analysis of cancer genomes reveals FEN1 drives formation of small inverted triplications through replication errors at nucleosome boundaries, with implications for structural variant mechanisms.
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PAF15-PCNA exhaustion limits strand-specific DNA replication control
Study reveals PAF15-PCNA interaction as a strand-specific constraint that couples lagging-strand synthesis capacity to global DNA replication control through dosage-sensitive mechanism.
