Focal Interest
Focal Interest

Nucleosome

  1. DNA replication errors linked to small inverted triplications
    Analysis of cancer genomes reveals FEN1 drives formation of small inverted triplications through replication errors at nucleosome boundaries, with implications for structural variant mechanisms.
  2. Review highlights histone marks in C. elegans embryonic cell cycle
    Explore histone modifications during C. elegans embryonic cell division, examining H4K20me1, H3S10ph, and other epigenetic marks that regulate chromatin dynamics and mitotic progression.
  3. SFPQ helps protect repeat DNA from R-loop damage
    SFPQ directs histone H3.3 deposition to R-loops in repetitive DNA elements through DAXX recruitment, suppressing replication stress and genome instability while activating innate immune responses.