Functional group
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Photocatalysis enabled synthesis of trifluoromethyl amidines and imidates Photocatalytic metal-free synthesis of α-trifluoromethyl amidines and imidates using isocyanides and trifluoroacetylsilanes, with mechanistic insights from DFT studies.
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Indole-based synthesis yields α-perfluoroalkylamino derivatives Novel sequential perfluoroalkylation and defluoroamination of indoles via sulfinate-derived radicals and HMDS-mediated C-F cleavage, yielding α-trifluoromethylated amines in up to 80% yield.