Focal Interest
Focal Interest

DNA replication

  1. DNA replication errors linked to small inverted triplications
    Analysis of cancer genomes reveals FEN1 drives formation of small inverted triplications through replication errors at nucleosome boundaries, with implications for structural variant mechanisms.
  2. PAF15-PCNA exhaustion limits strand-specific DNA replication control
    Study reveals PAF15-PCNA interaction as a strand-specific constraint that couples lagging-strand synthesis capacity to global DNA replication control through dosage-sensitive mechanism.
  3. Mycobacterial gyrase inhibition depends on DNA topology
    Study reveals that antibacterial drugs inhibit different gyrase-mediated catalytic activities at varying concentrations, with DNA topology modulating drug potency beyond DNA cleavage mechanisms.
  4. Mitotic repair pathway drives chromoanasynthesis
    Study reveals mitotic microhomology-mediated break-induced replication drives chromoanasynthesis, a complex chromosomal rearrangement mechanism in cancer and congenital disorders.
  5. SFPQ helps protect repeat DNA from R-loop damage
    SFPQ directs histone H3.3 deposition to R-loops in repetitive DNA elements through DAXX recruitment, suppressing replication stress and genome instability while activating innate immune responses.