Focal Interest
Focal Interest

Breakpoint

  1. DNA replication errors linked to small inverted triplications
    Analysis of cancer genomes reveals FEN1 drives formation of small inverted triplications through replication errors at nucleosome boundaries, with implications for structural variant mechanisms.
  2. A Spatio-Temporal Analysis Framework for Characterizing Radiation-Induced Genomic Instability
    Integrated analytical framework reveals 7.13-fold enrichment of doublet base substitutions at inversion breakpoints in chronic low-dose radiation exposure of human cells.