Focal Interest
Focal Interest

Bacterial Genetics and Biotechnology

External reference: https://openalex.org/T10120

  1. ComEC structure shows DNA cleavage and membrane translocation
    Cryo-EM structures reveal how ComEC cleaves double-stranded DNA and translocates single strands across bacterial membranes during natural transformation.
  2. PAF15-PCNA exhaustion limits strand-specific DNA replication control
    Study reveals PAF15-PCNA interaction as a strand-specific constraint that couples lagging-strand synthesis capacity to global DNA replication control through dosage-sensitive mechanism.
  3. H. pylori genome contains the dciA helicase loader gene
    Discovery of dciA gene in Helicobacter pylori challenges established chromosome replication models and reveals limitations in current helicase loader identification methodologies.