Focal Interest
Focal Interest

Advanced Electron Microscopy Techniques and Applications

External reference: https://openalex.org/T10857

  1. ComEC structure shows DNA cleavage and membrane translocation
    Cryo-EM structures reveal how ComEC cleaves double-stranded DNA and translocates single strands across bacterial membranes during natural transformation.
  2. Human Pol-PCNA binds DNA in an unexpected extra site
    Cryo-EM re-evaluation of human DNA polymerase epsilon-PCNA reveals unexpected multi-site DNA binding behavior contradicting prior mechanistic interpretations of mismatch recognition and proofreading.