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Category: Medicine

  • Heart-nosed bat alphacoronavirus uses human CEACAM6

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    What the study found A heart-nosed bat alphacoronavirus, CcCoV-KY43, was able to enter human cells by using the human receptor CEACAM6. The study also found direct interactions with human CEACAM3, CEACAM5, and CEACAM6, and showed that the virus’s receptor-binding domain binds the amino-terminal IgV-like domain of CEACAM6. Why the authors say this matters The authors…

  • Sparse MRI observations reconstructed cardiac displacement accurately

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    What the study found The study found that a Parametrized-Background Data-Weak (PBDW) approach can reconstruct three-dimensional cardiac displacement fields from sparse magnetic resonance image-like observations accurately. The authors also report two methodological additions: a minibatch worst-case orthogonal matching pursuit sensor-selection method and memory-optimization techniques for vectorial problems. Why the authors say this matters The authors…

  • MERA achieves lung nodule diagnosis with 1% annotated data

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    What the study found MERA is a multimodal and multiscale self-explanatory model for lung nodule diagnosis that uses considerably reduced annotation. The abstract reports that it achieves diagnostic accuracy comparable to or exceeding state-of-the-art methods with only 1% of annotated samples. Why the authors say this matters The authors state that MERA addresses gaps in…

  • Text messaging improved FIT completion over telephone outreach

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    What the study found Automated, behaviorally informed text message reminders were associated with higher fecal immunochemical test (FIT) completion than a nurse-led telephone call in this trial. The FIT is a low-cost stool test used for colorectal cancer screening. Why the authors say this matters The authors say scalable outreach strategies are needed to improve…

  • Vaccination in LMICs is often delayed beyond target ages

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    What the study found Many children in low-income and middle-income countries (LMICs) receive vaccines later than the ages recommended. Across 91 countries, the study found delays for several vaccines, including BCG, hepatitis B birth dose, polio, diphtheria-tetanus-pertussis-containing vaccines, pneumococcal conjugate vaccine, rotavirus vaccine, and measles-containing vaccine. Why the authors say this matters The authors conclude…

  • Delayed PCLR linked to more cartilage and meniscal injuries

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    What the study found The study found that delayed posterior cruciate ligament reconstruction (PCLR, surgery to repair the posterior cruciate ligament) was associated with more cartilage and meniscal injuries, especially when surgery was performed more than 24 months after injury. Older age and higher body mass index were also associated with a higher prevalence of…

  • Cognitive and respiratory issues were linked to poorer cardiac MR quality

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    What the study found Cognitive and communication impairment and respiratory compromise were independently associated with poor cardiac MR image quality. The associations remained after a sensitivity analysis that adjusted for repeat imaging. Why the authors say this matters The study suggests that identifying these pre-imaging clinical factors may help explain which patients are more likely…

  • Higher CKM stage was linked to higher cancer risk

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    What the study found Advancing cardiovascular-kidney-metabolic (CKM) syndrome stage was associated with higher cancer risk, especially at Stages 3 and 4. The association was reported in a large nationwide population and was consistent across cancer types and several subgroup analyses. Why the authors say this matters The authors conclude that the findings extend the clinical…

  • Alcohol use declined over 72 weeks of wearable membership

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    What the study found Self-reported alcohol consumption declined over the first 72 weeks of WHOOP wearable platform membership. The abstract reports that the daily probability of drinking fell by 5.8 percentage points, and that this reduction was seen across age groups and biological sex. Why the authors say this matters The abstract does not give…

  • Kansas naloxone recipients reported survival after reversals

    Kansas naloxone recipients reported survival after reversals

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    What the study found Community naloxone distribution programs in Kansas were linked, in survey responses, with reported opioid poisoning reversals and survival after naloxone use. The study also found barriers to consistent naloxone carriage and to seeking medical care after a reversal. Why the authors say this matters The authors conclude that naloxone distribution programs…