Category: Biology & Genetics
Fast and reliable association discovery in large-scale microbiome studies and meta-analyses using PALM
PALM, a quasi-Poisson regression framework, enables fast and reliable association discovery in large-scale microbiome studies by controlling false discovery rates and improving power.
Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair
Study reveals ATF4 regulates DNA repair genes critical for development of expanded upper cortical layers in mammalian brains, enabling progenitor survival under replicative stress.
Phytochemical Characterization and Biological Assessment of Geranium robertianum L. Ethanolic Extract on Human Salivary Gland Carcinoma Cells
Phytochemical characterization and antioxidant, antibacterial, and antiproliferative assessment of Geranium robertianum L. ethanolic extract on human salivary gland carcinoma cells.
Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks
Tel1-mediated negative feedback propagates locally to reshape genome-wide meiotic DSB patterns in yeast, demonstrating how localized regulation drives emergent patterning.
A Spatio-Temporal Analysis Framework for Characterizing Radiation-Induced Genomic Instability
Integrated analytical framework reveals 7.13-fold enrichment of doublet base substitutions at inversion breakpoints in chronic low-dose radiation exposure of human cells.
Explaining the unexplained admixture mapping signals via rare variants: the HCHS/SOL
Study finds common variants in extended genomic regions, not rare variants, explain most unexplained admixture mapping signals in Hispanic/Latino populations.
Chromosome-specific differences in the recombination landscape of spontaneous meiotic nondisjunction
Whole-genome sequencing of Drosophila reveals chromosome-specific recombination patterns in meiotic nondisjunction, with metacentric chromosome 2 showing reduced recombination.
