What the study found
Pregnant women with hypertensive disorders had higher cardiac and tissue injury biomarkers than normotensive pregnant women, and the levels rose with increasing severity from gestational hypertension to preeclampsia.
Why the authors say this matters
The authors conclude that the marked increase in NT-proBNP, a marker of ventricular wall stress, suggests significant cardiac stress and supports the potential role of these biomarkers in risk assessment and clinical monitoring.
What the researchers tested
The researchers conducted a cross-sectional study from May 2023 to May 2024 at a tertiary care hospital in Central India. They enrolled 312 pregnant women and grouped them as normotensive, gestational hypertension, or preeclampsia, then measured cardiac biomarkers including CPK-MB, LDH, SGOT, high-sensitivity C-reactive protein, troponin I, NT-proBNP, glucose, and creatinine.
What worked and what didn't
There was no significant difference in age or body mass index among the groups. Multiple biomarkers increased significantly as disease severity rose from gestational hypertension to preeclampsia, including NT-proBNP, troponin I, CPK-MB, SGOT, and LDH; NT-proBNP rose from 29 pg/mL in normotensive women to 40 pg/mL in gestational hypertension and 155 pg/mL in preeclampsia.
What to keep in mind
This was a cross-sectional study from a single tertiary care hospital in Central India, so the abstract does not describe longer-term follow-up or broader settings. The available summary does not state additional limitations.
Key points
- The study compared biomarker levels in 312 pregnant women with and without hypertensive disorders.
- Biomarkers increased stepwise from gestational hypertension to preeclampsia.
- NT-proBNP rose from 29 pg/mL in normotensive women to 155 pg/mL in preeclampsia.
- Troponin I, CPK-MB, SGOT, and LDH were significantly elevated in hypertensive disorder groups.
- No significant differences were found in age or body mass index across groups.
Disclosure
- Research title:
- Hypertensive pregnancy linked to higher cardiac biomarker levels
- Authors:
- Pawan Kumar Kare, Tripti Saxena, Haresingh Makwane, Pallavi Singh, Shubhishee Joshi
- Publication date:
- 2026-02-25
- OpenAlex record:
- View
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