Analysis of Laboratory and Obstetric Outcomes in Preeclampsia: A Comparative Study of Bolu and Şanlıurfa

Key findings from this study

This research indicates that:

• Systolic and diastolic blood pressure elevations, liver enzyme elevations (AST and ALT), gravidity, and parity were significantly higher in Şanlıurfa compared to Bolu.
• Proteinuria was more frequent in Bolu but more severe in Şanlıurfa.
• Rh antigen positivity was more common among preeclamptic pregnancies across both centers.
• Preeclamptic pregnancies in Şanlıurfa exhibited more severe laboratory findings and higher complication rates than those in Bolu.

Overview

A retrospective comparative analysis of laboratory and obstetric outcomes in preeclamptic pregnant women across two clinical centers in Turkey. The study examined biochemical markers, hemogram values, and delivery outcomes in 435 pregnant women diagnosed with preeclampsia.

Methods and approach

Retrospective analysis of preeclamptic pregnancies presenting to obstetrics clinics in Şanlıurfa (n=363) and Bolu (n=72). Investigators reviewed biochemical data, hemogram values, and obstetric records to identify between-center differences in disease presentation and maternal outcomes.

Results

No significant differences emerged between centers regarding maternal age, hemoglobin levels, or delivery mode. Şanlıurfa patients demonstrated significantly elevated systolic and diastolic blood pressures, liver enzymes (AST, ALT), gravidity, and parity compared to Bolu patients. Proteinuria frequency exceeded that in Bolu, though proteinuria severity was greater in Şanlıurfa patients.

Rh antigen positivity was more common in the preeclamptic population overall. The clinical profile diverged markedly between centers: Şanlıurfa patients exhibited more pronounced laboratory abnormalities and a higher incidence of preeclampsia-related complications than Bolu patients.

Implications

Geographic or demographic variations in preeclampsia presentation may reflect differences in maternal population characteristics, disease progression patterns, or clinical management protocols across study sites. The disparity in blood pressure elevations, transaminase levels, and proteinuria severity suggests that patient populations or disease trajectories differed substantially between centers, warranting investigation of underlying clinical or demographic factors.

These findings underscore the importance of center-specific or population-specific outcome data when evaluating preeclampsia management strategies. Clinical protocols may require adjustment to account for regional variation in disease severity and complication rates.

Scope and limitations

This summary is based on the study abstract and available metadata. It does not include a full analysis of the complete paper, supplementary materials, or underlying datasets unless explicitly stated. Findings should be interpreted in the context of the original publication.