What the study found
The review argues that brain health and resilience are important for understanding late-life neuropsychiatric and neurodegenerative disorders. It describes brain health as a dynamic balance of neural, cognitive, and emotional processes and says resilience may be a modifiable pathway connected to illness risk and prevention.
Why the authors say this matters
The authors conclude that a whole-person, life-course approach may be valuable for promoting healthy brain aging. They suggest that linking resilience mechanisms to measurable biological indices could help inform next-generation strategies in neuropsychopharmacology, prevention science, and healthy brain aging.
What the researchers tested
This is a review article that synthesizes current evidence on determinants of brain health in aging. The authors integrate findings from neuroscience, lifestyle medicine, geroscience, and social determinants of health, and they also consider brain clocks, precision biomarkers, digital phenotyping, and artificial intelligence as tools for risk stratification, early detection, and personalized intervention.
What worked and what didn't
The review emphasizes interplay among stress physiology, interoceptive regulation, emotional resilience, and cognitive and brain reserve across aging. It does not report new experiments or provide direct test results in the abstract, but instead presents an argument for integrating neurobiological, psychological, behavioral, and sociocultural domains.
What to keep in mind
This is a narrative synthesis, so the abstract does not describe a single study sample, intervention, or quantified outcome. Limitations are not described in the available summary.
Key points
- The review links brain health and resilience to trajectories of late-life neuropsychiatric and neurodegenerative disorders.
- Brain health is defined as a balance of neural, cognitive, and emotional processes.
- The authors describe resilience as a modifiable pathway related to risk and prevention.
- The paper considers brain clocks, precision biomarkers, digital phenotyping, and artificial intelligence for risk stratification, early detection, and personalized intervention.
- The abstract does not report new experimental results or a study sample.
Disclosure
- Research title:
- Review links brain health and resilience to healthy aging
- Authors:
- Helen Lavretsky, Sahib S. Khalsa, Hanadi Ajam Oughli, Agustin Ibanez, Josefina Cruzat, Emmeline Edwards, Paul Newhouse, Claudio L. A. Bassetti, Indrit Bègue, Andrea Sylvia Winkler, Dilip V. Jeste, Harris Eyre
- Institutions:
- Neurobehavioral Systems, University of California, Los Angeles, Trinity College Dublin, Adolfo Ibáñez University, National Center for Complementary and Integrative Health, Vanderbilt University Medical Center, University Hospital of Bern, University Hospital of Geneva, Geneva College, University of Oslo, Technical University of Munich, Health Net, Rice University
- Publication date:
- 2026-01-28
- OpenAlex record:
- View
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